L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis

Xiaowei Dou,Carrie E. Menkari,Rei Mitsuyama,Tatiana Foroud,Leah Wetherill,Peter Hammond,Michael Suttie,Xiaopan Chen,Shao-yu Chen,Michael E. Charness,Collaborative Initiative on Fetal Alcohol Spectrum Disorders

L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis

2018

Xiaowei Dou
Carrie E. Menkari
Rei Mitsuyama
Tatiana Foroud
Leah Wetherill
Peter Hammond
Michael Suttie
Xiaopan Chen
Shao-yu Chen
Michael E. Charness
Collaborative Initiative on Fetal Alcohol Spectrum Disorders

Ethanol causes fetal alcohol spectrum disorders (FASDs) partly by inhibiting cell adhesion mediated by the L1 neural cell adhesion molecule. Ethanol interacts with an alcohol binding pocket in the ...

Keywords:

Adhesion
Ankyrin
Phosphorylation
Cytoskeleton
Cell biology
Actin
Chemistry
Spectrin
Ethanol
actin cytoskeleton

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