Exenatide improving antioxidant ability of nonalcoholic fatty liver disease of rats

Objective To investigate the exenatide effect on fat-induced nonalcoholic fatty liver disease(NAFLD) of rat. Methods NAFLD models were established after 12 weeks of high fat diet feeding,a total of 120 SD rats were randomly divided into control group(CON group),model group(HFD group),exenatide low,medium,high dose group(ELD group,EMD group,EHD group) and polyene phosphatidylcholine treatment group(PDC group),with 20 rats in each group.After given appropriate treatment,half of the rats were sacrificed after 4 and 8 weeks.HE staining of liver slices,antioxidant factors were performed. Results With the dose of exenatide became larger,and the time got longer,the liver fat and the inflammatory response were significantly reduced and the fat particles were significantly reduced; serum and liver total antioxidant capacity was significantly improved. Conclusion Exenatide improves antioxidant ability of NAFLD of rats. Key words: Non-alcoholic fatty liver disease; Exenatide; Antioxidant ability