Low Prevalence of Subclinical Atherosclerosis in Asymptomatic Patients With Type 1 Diabetes in a

Most patients with type 1 diabetes and control subjects displayed a CACS of 0 (82 vs. 92%). Patients with type 1 diabetes with CACS ‡ 1w ere older and had higher HbA1c(44.565.1 vs. 36.768.1 years [P<0.001] and 8.561.1 vs.7.861.0% [P< 0.003], respectively) and longer evolution of diabetes (25.4 6 9.2 vs. 19.3 6 7.4 years, P < 0.005) and mean c-IMT (0.67 6 0.18 vs. 0.53 6 0.11 mm, P < 0.001) compared with patients with CACS of 0. Smoking (P < 0.02), nephropathy (P < 0.05), retinopathy (P < 0.05), and male sex (P < 0.03) were significantly and positively associated with CACS ‡1. Mean c-IMT was significantly higher in patients with type 1 diabetes (0.55 6 0.14 vs. 0.48 6 0.14 mm, P < 0.01), and 11% of them presented atheroma plaques (8% of control subjects). Multivariant logistic regression analysis showed that c-IMT was related to CACS (b = 6.87, P < 0.001). CONCLUSIONS