Changes of TIZ expression in epithelial ovarian cancer cells

Abstract Objective To study the change of TIZ expression in epithelial ovarian cancer cells. Methods HO8910 cells were transinfected with siRNA to inhibit the expression of TIZ. pcDNA3.1–TIZ vectors were combined to increase the TIZ expression level. The cell viability, colony forming efficiency and cycle distribution of HO8910, HO8910/NC, HO8910/pcDNA3.1–NC, HO8910/TIZ–573 and H08910/pcDNA3.1–TIZ were compared, and the invasion rate, migration rate and adhesion rate between 5 groups of cells were compared. Results Compared with those of HO8910, HO8910/NC and HO8910/pcDNA3.1–NC, the cell viability, colony forming efficiency and cell cycle distribution of HO8910/TIZ–573 were increased, while the indexes of H08910/pcDNA3.1–NC were decreased with statistical significant difference ( P P >0.05). Conclusions The expression of TIZ can inhibit the proliferation of epithelial ovarian cancer cells.