Clinical and serological profile of primary biliary cirrhosis in men

Sir, Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by a high ratio of women to men (9:1).1,,2 Little is known about the clinical expression of PBC in men, since the rarity of this disease in males makes it difficult to enrol sufficient numbers in a study. We analysed the clinical profile of male patients with PBC at presentation, and compared them with a control group of their female counterparts. Thirty consecutive men and 165 women who satisfied the established criteria for the diagnosis of PBC were included.3 Clinical history, physical examination, and routine biochemical and immunological tests were done …