Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection.

Mopo Radebe,Kamini Gounder,Mammekwa Mokgoro,Zaza M. Ndhlovu,Zenele Mncube,Lungile Mkhize,Mary van der Stok,Manjeetha Jaggernath,Bruce D. Walker,Thumbi Ndung'u

Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection.

2015

Mopo Radebe
Kamini Gounder
Mammekwa Mokgoro
Zaza M. Ndhlovu
Zenele Mncube
Lungile Mkhize
Mary van der Stok
Manjeetha Jaggernath
Bruce D. Walker
Thumbi Ndung'u

Objective We characterized protein-specific CD8+ T-cell immunodominance patterns during the first year of HIV-1 infection, and their impact on viral evolution and immune control.

Keywords:

Virology
Medicine
Immunodominant Epitopes
Immunology
Immune system
CD8
Cytotoxic T cell
Interferon gamma
Immunodominance
Viral evolution
Viral load
ELISPOT
Epitope
Seroconversion
Group-specific antigen

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