Benzopyran sulfonamides as KV1.5 potassium channel blockers.

John Lloyd,Karnail S. Atwal,Heather Finlay,Michael Nyman,Tram Huynh,Rao S. Bhandaru,Alexander Kover,Joan B. Schmidt,Wayne Vaccaro,Mary Lee Conder,Tonya Jenkins-West,Paul Levesque

Benzopyran sulfonamides as KV1.5 potassium channel blockers.

2007

John Lloyd
Karnail S. Atwal
Heather Finlay
Michael Nyman
Tram Huynh
Rao S. Bhandaru
Alexander Kover
Joan B. Schmidt
Wayne Vaccaro
Mary Lee Conder
Tonya Jenkins-West
Paul Levesque

Abstract K V 1.5 blockers have the potential to be atrium-selective agents for treatment of atrial fibrillation. The benzopyrans provide a template for the synthesis of potent and selective K V 1.5 blockers.

Keywords:

Chemical synthesis
Antiarrhythmic agent
Potassium channel
Potassium
Organic chemistry
Ion channel blocker
Stereochemistry
Benzopyrans
Benzopyran
Potassium channel blocker
Chemistry
Pharmacology

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