Meta-analysis of the effect of physical training on physiological function of adult renal transplant recipients

Objective To assess the impact of physical training on physiological function of adult renal transplant recipients by meta-analysis and to provide theoretical guidance for clinical practice. Methods Randomized controlled trials of physical training for the treatment of renal transplant recipients until October 2017 were searched in the database of Cochrane library, PubMed, Embase, Web of Science, Wanfang Data and CNKI. Data extracted from the literatures were analyzed with RevMan software (version 5.3). Results A total of 10 studies in 10 manuscripts met the inclusion criteria, and 557 cases were included. Meta-analysis results were as follows. Compared with the control group (routine drug therapy), the level of peak exercise oxygen uptake (peak VO2) was significantly increased in physical training group (routine drug therapy and physical training) (MD=2.40, 95%CI 0.15-4.64, P=0.04). However, there was no statistically significant difference in the change of blood lipid, blood pressure, hemoglobin and serum creatinine between the two groups (all P>0.05). Conclusions Physical training can improve cardio respiratory fitness of renal transplant recipients in the early stage, but it has no obvious effect on blood pressure, blood lipid, hemoglobin and blood creatinine. Key words: Meta-analysis; Exercise; Kidney transplantation; Randomized controlled trial