Massive locally extensive prostate cancer.

A massive, locally extensive adenocarcinoma of the prostate (2,246 ccm) presenting as constipation and a palpable abdominal mass, was treated with androgen deprivation resulting in a 94 percent reduction in tumor size, and relief of symptoms. Serum prostate-specific antigen was reduced from 4,029 to 0.4 ng/mL, after hormonal therapy was combined with radiation treatments for local disease control.