Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies.

Gwo-Yu Chuang,Mangaiarkarasi Asokan,Vera B. Ivleva,Amarendra Pegu,Eun Sung Yang,Baoshan Zhang,Rajoshi Chaudhuri,Hui Geng,Bob C. Lin,Mark K. Louder,Krisha McKee,Sijy O'Dell,Hairong Wang,Tongqing Zhou,Nicole A. Doria-Rose,Lisa A. Kueltzo,Q. Paula Lei,John R. Mascola,Peter D. Kwong

Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies.

2020

Gwo-Yu Chuang
Mangaiarkarasi Asokan
Vera B. Ivleva
Amarendra Pegu
Eun Sung Yang
Baoshan Zhang
Rajoshi Chaudhuri
Hui Geng
Bob C. Lin
Mark K. Louder
Krisha McKee
Sijy O'Dell
Hairong Wang
Tongqing Zhou
Nicole A. Doria-Rose
Lisa A. Kueltzo
Q. Paula Lei
John R. Mascola
Peter D. Kwong

Broadly neutralizing antibodies are showing promise in the treatment and prevention of HIV-1, with several now being evaluated clinically. Some lead clinical candidates, including antibodies CAP256...

Keywords:

Virology
human immunodeficiency virus
Antibody
N-linked glycosylation
Homogeneity (statistics)
Biology
variable domain

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