MARCO Gene Variations and Their Association with Cardiovascular Diseases Development: An In-Silico Analysis.

Cardiovascular diseases (CVDs) represent the leading cause of morbidity and mortality in both developed and developing countries. They have complex etiology, influenced by several risk factors including the genetic component. The genetic variations were shown to be highly associated with different CVD forms, in this objective we proceeded to analyze the Macrophage Receptor with Collagen structure gene (MARCO), we performed an in-silico study with a genomic functional analysis, to evaluate the mutations’ effects on the proteins’ structures and functionalities. Indeed, we used dbSNP to retrieve single nucleotide polymorphisms (SNPs) of MARCO gene. We proceeded then to a filtration and a stability analysis using several bioinformatics tools to evaluate the most deleterious variations. Moreover we predicted the 3D structures of the encoded proteins by MARCO gene, which was validated using PROCHECK. Then we analyzed and visualize the proteins’ 3D structures.