Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer.

ObjectivesWe have established rat models of pancreatic ductal adenocarcinoma (PDAC) in which expression of a human H-rasG12V or K-rasG12V oncogene regulated by the Cre/lox system drives pancreatic carcinogenesis. Pancreatic ductal adenocarcinoma which develops in H-rasG12V and K-rasG12V transgenic r