Periurethral Vaginal Adenocarcinoma of the Intestinal Type: Report of Two Cases and Review of the Literature

Abstract Introduction. Vaginal adenocarcinomas in the absence of diethylstilbestrol (DES) exposure are rare neoplasms. Only a few cases with enteric type histology have been reported. Also rare are urethral adenocarcinomas in women. Case reports. Two cases of vaginal adenocarcinoma of the intestinal type in the absence of DES exposure are presented. Both cases arose in the periurethral area, raising the issue of urethral as well as vaginal origin. Discussion. The possible histogenesis of these neoplasms is considered.