Induction of HSP70 Genes in the Mammalian Nervous System by Hyperthermia, Tissue Injury and Other Traumatic Events

The induction of heat shock proteins has been studied in a wide range of organisms Including E. coli, yeast, Drosophila and eukaiyotic cells grown in culture (Pardue et al., 1989), however, comparatively little work has been carried out on intact thermoregulating animals. In this laboratory we are exploring whether the heat shock response is turned on in the mammalian nervous system following such traumatic conditions as fever-like temperatures and tissue wounding, and if so, which cell types show induction.