Is Her-2/neu expressed in nonepithelial ovarian malignancies?

Objective The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies. Study design Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. Results Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined. Conclusion Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.