Identification of compounds that modulate smyd3 transferase for the treatment of cancer

The present invention, modulators of methods and methyltransferase activity detecting the methyltransferase activity of the polypeptide, more specifically features a method of screening for modulators of methylation of retinoblastoma by SMYD3. Furthermore, the present invention uses the thus identified modulators, colorectal cancer, hepatocellular carcinoma, a method or a pharmaceutical composition for preventing or treating bladder cancer and / or breast cancer. N-terminal truncated SMYD3 (aliasZNFN3A1) have higher methylation activity. Lys824 is a preferred methylation sites on the RB1 protein SMYD3.