Use of indirubin derivative for preparing medicines for treating nerve retrograde affection

The present invention relates to an application of indirubin derivative (IO) in the preparation of medicine for curing neural retrograde disease, specially, it relates to an application of indirubin derivative in the preparation of medicine for curing Parkinson's disease. Said invention uses the indirubin derivative as inhibitor and utilizes three kinds of mediated and died kinases of JNK/CDK5/GSK3 beta which are inhibited by said indirubin derivative as clear target to develop the invented new medicine.