Comparison between 1300 nm and 800 nm OCT imaging of ex vivo human esophageal tissues

The feasibility of ultrahigh-resolution OCT capsule endoscopy working at 800 nm was demonstrated by imaging ex vivo freshly resected human esophageal tissues, and its performance was compared with conventional volumetric laser endomicroscopy (VLE) working at 1300 nm. The results showed that the ultrahigh-resolution capsule can identify histology-confirmed diagnostic features with much finer details and contrast, particularly in mucosal layers, and demonstrated its promising potential of differentiating pathological changes in earlier stages.