Synthesis method of rosuvastatin calcium key chiral intermediate

The invention discloses a synthesis method of a rosuvastatin calcium key chiral intermediate and belongs to the technical field of synthesis of medical intermediates. According to the technical scheme, the method is characterized as the specification. With the adoption of the process route, use of an expensive medicine, namely, ethyl (R)-4-bromo-3-hydroxybutyrate, is avoided, the ee (enantiomeric excess) value of a product is effectively increased due to use of a chiral catalyst, raw materials of the synthesis method are simple and easy to obtain, the route is simple to operate, the repeatability is good, the yield is very high, and the method is suitable for industrial production.