The effect of cellulose ethers on indomethacin/cyclodextrin complexation

Cyclodextrins (CD) are water-soluble, hydrophobic torus-shaped cyclic oligosacharides that can accommodate in their cavities water-insoluble drugs to form water-soluble inclusion complexes. Because of these properties CD have been used to enhance drug solubility, to stabilize formulations, and to increase the bioavailability of drugs (1). Natural and chemically modified CD are biocompatible polymers and are regarded as relatively safe for therapeutic applications (2). Particullary safe profile as parenteral and ophtalmic drug delivery systems were evaluated on drug/hydroxypropyl-s-cyclodextrin (HPsCD) complexes (3). A many publication dealing with effect of different vehicle additives commonly used in drug formulation such as polymers, non-ionic surfactants, buffer salts, preservatives, which could be reduced the CD abilities of drug complexation (3,4).