EXPEDIENT ENANTIOSPECIFIC SYNTHESIS OF RP 73613 : A NEW SELECTIVE NON-PEPTIDE NK1 ANTAGONIST

The synthesis of RP 73613 was achieved in 13 steps with an overall yield of 125. The strategy was based on a [3+2] azomethine ylid dipolar cycloaddition to generate the bicyclic framework and the asymmetry was introduced by resolution.