Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure

This conceptually powerful study illuminates how the effects of oncogene activation extend beyond well-studied cell autonomous roles in proliferation, apoptosis, and invasion to suppressive effects on the local immune microenvironment, which are essential to license immune escape as the critical step in tumorigenesis.