One-step Synthesis of 2-Hydroxy-2-(trifluoromethyl)malonates by Trifluoromethylation of 2-Oxomalonates with Ruppert-Prakash Reagent

Kazuki Hirano,Kotaro Yoshioka,Kazuto Umezu,Takumi Kagawa,Yuji Sumii,Norio Shibata

One-step Synthesis of 2-Hydroxy-2-(trifluoromethyl)malonates by Trifluoromethylation of 2-Oxomalonates with Ruppert-Prakash Reagent

2020

Kazuki Hirano
Kotaro Yoshioka
Kazuto Umezu
Takumi Kagawa
Yuji Sumii
Norio Shibata

The one-step synthesis of 2-hydroxy-2-(trifluoromethyl)malonates is described. The nucleophilic trifluoromethylation of commercially available 2-oxo-malonates was possible by use of the Ruppert-Pra...

Keywords:

Trifluoromethylation
Reagent
Trifluoromethyl
One-Step
Chemistry
Organic chemistry
Malonate
Nucleophile

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