Changes in the kinetic properties of aldolase and lactate dehydrogenase in the brain cytoplasm of mice following chronic gamma irradiation at low doses

: The effect of chronic low-dose (0.6 rad/day) 137Cs gamma-irradiation of mice was studied. It was shown that radiation causes changes in the kinetic parameters (Vmax, KM, Vmax/KM) and isoenzyme patterns of aldolase and lactate dehydrogenase of the brain cytoplasm of mice. The kinetic properties of both enzymes changes in 1, 2, 4 and 9 days after irradiation. The character of changes in Vmax of these enzymes depends on the original Vmax values. The level of the predominant LDH1 (H4) form increases while that of the specific tissular form (C4) decreases (acute on the 9th day). Different levels of sensitivity of aldolase, LDH, and their isoenzymes to low-doses of low-rate gamma-irradiation were observed.