Role of TLR5 in infectious diseases

Toll-like receptor 5 (TLR5) is one of the pattern recognition receptors and recognizes the flagellin protein of bacteria. It activates innate immune responses and induces production of a series of cytokines. TLR5 functions as a bridge linking innate and adaptive immunities. It is known that TLR5 plays an important role in the occurrence and development of certain infectious diseases. This review summarizes the relationships of TLR5 polymorphisms with the development of infectious diseases and discusses the possible pathogenesis. Key words: TLR5; Infectious diseases; HBV infection; Cytokine; Gut microbiota