Identification of two cancer-associated fibroblast markers revealing stromal heterogeneity in sustaining cancer progression and chemoresistance

Chronic inflammation is central to the pathogenesis of atherosclerosis and metabolic syndrome, and promotes both formation and rupture of atherosclerotic plaques, which account for ischemic complications of cardiovascular disease (CVD) (1,2). Pro-inflammatory cytokines and chemokines including interleukin-1 (IL-1) as well as adhesion molecules intercellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM), which are highly expressed in atherosclerotic lesions and on layering endothelial cells, promote leukocyte recruitment, impair vasodilation, and induce oxidative stress and pro-coagulant mediators (3-5).