Изучение эффекта стимуляции яичников крыс препаратами Оваринин и Фоллигон

There was evaluated the preventive effect of the drug Ovarinin on the follicle formation process at subsequent administration of the follicle-stimulating drug Folligon. The laboratory Wistar rats divided into one control and two experimental groups were used as the object of the study. The isotonic NaCl solution was administered subcutaneously to the control animals, Folligon to the rats of the first test group, and Folligon and Ovarinin to the second group. The drug Folligon of pregnant mares’ serum gonadotropin caused drastic morphological changes in the ovaries manifested in the 2-2.5 time increased cell nuclei size, increased cell size, saturation of the cytoplasm with structural elements, enhanced cell division process. After stimulation was observed the increase in the size of both ovaries; the intense maturation of follicles and the ovulation occurred. As influenced by hormonal stimulation against the background of the homeopathic drug Ovarinin was observed the 2-2.5 time increase in cell nuclei size as compared with the histological preparations of the control group, hypertrophy of the cell material in the medulla of the ovary with increased content of structural elements. The enhancement of the cell division process, proliferation and lumen increase of the blood vessels network were less pronounced than those in the first test group. The application of Folligon against the background of Ovarinin was accompanied by less drastic morphological changes as compared with the effect in the Folligon mono-variant, the ovulation in the ovaries was much less often. The combined application of the drugs studied drastically reduces a possibility of formation of the ovarian cysts due to hyperstimulation by PMSG drugs. This is significative of the fact that the homeopathic drug prevents the development of ovarian cysts at hormonal imbalance as well as of the efficacy of the combined use of hormonal and homeopathic preparations possessing a mild and effective neuro-hormonoregulation activity.