5-Formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively

TET2 is one of the most commonly mutated genes in adult myeloid malignancies, occurring in approximately 25% and approximately 50% of cases of myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML),[1][1]–[3][2] respectively. TET2 protein is a dioxygenase that converts 5-