Anibamine, a Natural Product CCR5 Antagonist, as a Novel Lead for the Development of Antiprostate Cancer Agents.

It is demonstrated that anibamine (I), a recently isolated alkaloid from Aniba species, produces significant inhibition of prostate cancer cell proliferation at micromolar to submicromolar concentrations as well as suppressing adhesion and invasion of the highly metastatic M12 prostate cancer cell line.