The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Bernardo S. Franklin,Lukas Bossaller,Dominic De Nardo,Jacqueline M Ratter,Andrea Stutz,Gudrun Engels,Christoph Brenker,Mark Nordhoff,Sandra R Mirandola,Ashraf Al-Amoudi,Matthew Mangan,Sebastian Zimmer,Brian G. Monks,Martin Fricke,Reinhold E. Schmidt,Terje Espevik,Bernadette Jones,Andrew G. Jarnicki,Philip M. Hansbro,Patricia Busto,Ann Marshak-Rothstein,Simone Hornemann,Adriano Aguzzi,Wolfgang Kastenmüller,Eicke Latz

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

2014

Various endogenous and pathogen-derived stimuli trigger the assembly of cytosolic multimolecular 'speck' platforms coordinated by the adapter ASC. Latz and colleagues demonstrate that ASC specks have extracellular functions that can prolong inflammation.

Keywords:

Cell biology
AIM2
Inflammation
Immunology
Cytoskeleton
Innate immune system
Cell signaling
Caspase 1
Extracellular
Signal transduction
Biology
CARD Signaling Adaptor Proteins

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