The Prediction Value of the Systemic Inflammation Score for Oral Cavity Squamous Cell Carcinoma

ObjectivesThis study aimed to investigate the potential prognostic role of the oral cancer systemic inflammation score (SIS) based on serum albumin levels and the lymphocyte-to-monocyte ratio in patients with oral squamous cell carcinoma (OSCC) after treatment.Study DesignA retrospective cohort study.SettingTertiary care center.Subjects and MethodsThe study involved 613 patients who were treated for OSCC between September 2005 and December 2014. The association of the oral cancer SIS with various clinicopathological features was investigated. A nomogram based on different clinicopathological features and SIS was established to predict prognosis.ResultsHigher SIS was significantly associated with older age (P = .0013), advanced tumor status (P < .0001), tumor depth (P < .0001), advanced overall pathologic stage (P < .0001), and extranodal extension (P = .0045), as well as the presence of perineural invasion (P = .0341). Higher SIS, older age, overall stage, and extranodal extension were demonstrated to be ...