INFLUENCE OF 2,4-DINITROPHENOL ON ANION TRANSPORT BY AN INTESTINAL IN VITRO PREPARATION.

RECENT observations carried out on isolated and in vitro perfused preparations of the small intestine of the rat have confirmed that sodium is actively transported through the intestinal wall from the mucosal to the serosal side1–5. For such a transport glucose must be present in the mucosal solution; some metabolic inhibitors, 2,4-dinitrophenol (DNP) or monoiodoacetate, when added to the perfusion liquid, inhibit this transport2,6. The chloride ions cross the intestinal wall together with cations and for the transport of these ions, too, an active mechanism has been assumed3,7.