OPTIMIZATION OF FAST DISINTEGRATING TABLETS FOR DICLOFENAC SODIUM USING ISABGOL MUCILAGE AS SUPER DISINTEGRANT

Fast disintegrating tablets used for administration in the oral cavity were prepared either by direct compression or by wet granulation method. The The disintegration time of conventional tablets was reduced from 10 minutes to a minimum of 23 seconds by introducing 2-5% of dried isabgol extract. By optimizing moisture content of the granules, tablets meeting tensile strength greater than 0.6 MPa and disintegration time shorter than 100 s were obtained by the wet compression method. The tensile strength of the tablet increased remarkably in tablets prepared by wet granulation process, while the porosity of the tablet seemed almost unchanged. Superdisintegrant features of isbagol was further optimized by water absorption and in vitro dispersion time. Wetting time and disintegration time matched with the requirements of EP, Dissolution profiles suggested that the superdisintegrants action of the dried isabgol mucilage enhanced the release of the drug from tablets with respect to conventional marketed. Moreover, Directly compressed tablets released drug rapidly as compared to wet granulation process. By an appropriate combination of excipients it was thus possible to obtain rapidly disintegrating tablets and a rapid release of diclofenac sodium using simple and conventional manufacturing techniques. The storage conditions of tablets produced no significant changes (p<0.05) eliciting stability of isabgol as superdisintegrant. Therefore, we concluded that the formulating ratio of 2-5 % of the dried isabgol mucilage in the tablet is suitable for the rapidly disintegrating tablet in the mouth when