OF AUTOCHTHONOUS TUMOR CELLS IN CANINE LYMPHOMA

The feasibility of repeated intralymphatic injections of cellular materials was investigated in dogs having spontaneous lymphomas. Forty-two administrations of enzymatically-modified irradiated sutochthonous tumor cell preparations were performed with minimal difficulty and negligible deleterious side effects, indicating that the intralymphatic route of administration and these methods of cell vaccine preparation may be safely used for further pre-clinical investigations. Although the number of animals treated thus far is insufficient to realistically evaluate the immunotherapeutic potential of this method, all treated tumor-bearing dogs demonstrated marked reduction in tumor volume and significant clinical improvement.