IMPACT OF NON-SURGICAL PERIODONTAL TREATMENT ON SERUM TNF-α LEVELS IN INDIVIDUALS WITH TYPE 2 DIABETES: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract Objective: The objective of this systematic review and meta-analysis was to search for scientific evidence on the impact of non-surgical periodontal therapy on tumor necrosis factor alpha (TNF-α) in type 2 diabetics. Methods: The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement has been followed. The study was registered (CRD42020192790) in the International prospective register of systematic reviews (PROSPERO). Searches were conducted in five databases. Restrictions on publication date were not imposed in anyway. The studies reporting the serum TNF-α levels of individuals with type 2 diabetes mellitus (DM) before and after non-surgical periodontal therapy were included. Studies’ selection, extraction of data and risk of bias assessment were performed in duplicate. Consensus was achieved. Meta‐analysis was carried out. The 95% confidence interval (CI) and odds ratio (OR) were provided. Results: Six hundred and twenty-three references were retrieved and eighteen studies were included. Meta-analysis demonstrated that the serum levels of TNF-α in individuals with type 2 DM decreased six months after non-surgical periodontal therapy (mean difference = -1.90, confidence interval = -3.05 – -0.74). Included studies presented low risk of bias. Conclusion: Non-surgical periodontal therapy has an impact on serum TNF-α levels at six months in type 2 DM patients.