Effects of the standardized Panax ginseng extract G115 on the D-glucose transport by Ehrlich ascites tumour cells

The effect of standardized Panax ginseng extract (G115 Pharmaton) on D-glucose uptake by Ehrlich ascites tumour cells from mouse was examined. Measurements were carried out using [ 3 H]-2-deoxy-D-glucose, a non-metabolizable glucose analogue. [ 3 H]-2-deoxy-D-glucose was transported from the medium to cells and phosphorylated but was neither further metabolized nor eliminated. Thus, the amount taken in the cells was a measure of D-glucose uptake. The results showed that G115 stimulated D-glucose transport and the maximum effect was obtained at a G115 concentration of 2.0 μg/mL representing an increase of about 35% above basal activity