Inflammatory breast cancer cells are characterized by abrogated TGFβ1-dependent cell motility and SMAD3 activity

C. Rypens,Melike Marsan,Christophe Van Berckelaer,C. Billiet,Kirsten Melis,Sara Perez Lopez,Peter van Dam,Gayathri R. Devi,Pascal Finetti,Naoto T. Ueno,François Bertucci,Piet Dirix,Patrick Neven,Peter B. Vermeulen,Luc Dirix,Steven Van Laere

Inflammatory breast cancer cells are characterized by abrogated TGFβ1-dependent cell motility and SMAD3 activity

2020

C. Rypens
Melike Marsan
Christophe Van Berckelaer
C. Billiet
Kirsten Melis
Sara Perez Lopez
Peter van Dam
Gayathri R. Devi
Pascal Finetti
Naoto T. Ueno
François Bertucci
Piet Dirix
Patrick Neven
Peter B. Vermeulen
Luc Dirix
Steven Van Laere

Purpose Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with elevated metastatic potential, characterized by tumor emboli in dermal and parenchymal lymph vessels. This study has investigated the hypothesis that TGFβ signaling is implicated in the molecular biology of IBC.

Keywords:

Motility
Cancer research
Medicine
Parenchyma
Inflammatory breast cancer
Lymph
Breast cancer
Gene
Cell culture
SMAD
Transcription factor
Primary tumor
Gene expression

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