The first asymmetric total synthesis of several 3,4-dihydroxy-2,2-dimethyl-chroman derivatives

Abstract The stereoisomers of 3,4-dihydroxy-6-methoxy-2,2-dimethyl-chroman 1a – c and 3,4,7-trihydroxy-6-acetyl-2,2-dimethyl-chroman 2a – c were conveniently prepared for the first time via a synthesis in which Sharpless asymmetric dihydroxylation and Jacobsen’s catalytic asymmetric epoxidation are the key steps.