Роль сывороточных маркеров синтеза и деградации коллагена, структурно-функциональных параметров сердца в прогнозировании фибрилляции предсердий у пациентов с синдромами преждевременного возбуждения желудочков

Aim. The aim of the study was to optimize the diagnosis and prognosis of developing arrhythmias in this cohort and to reveal the possible role of fibrous matrix disturbance in development of arrhythmia. Materials and methods. The main group included 43 patients with premature ventricular excitation syndromes (WPW phenomenon, WPW syndrome), the comparison group 15 practically healthy persons of the similar age. The mean age of patients belonging to the main group was 25,3 ± 9,15 years. All the groups were comparable by gender distribution ( p = 0,45, Fisher criterion) and age ( p = 0,27, U-criterion). Results. The greatest matrix metalloproteinase-9 (MMP-9) indices were assessed in patients with WPW syndrome 96,1 ± 33,2 ng/ml, with WPW phenomenon 54,3 ± 21,8 ng/ml; p = 0,0003). Practically healthy persons had minimum MMP-9 values 27,4 ± 10,9 ng/ml ( p = 0,00014; p = 0,000002). Maximum values of tissue inhibitor of matrix metalloproteinases (TI MP-1) are presented in WPW phenomenon group and practically healthy persons (418,5 ± 69,8 ng/ml and 461,7 ± 72,2 ng/ml; p = 0,27). In patients with WPW syndrome, TIMP-1 was reliably lower 341,1 ± 90,1 ng/ml ( p = 0,002; p = 0,00012). Procollagen type 1 carboxyterminal propeptide (PICP) level in patients with WPW syndrome was 179,9 ± 76,2 ng/ml, with WPW phenomenon 97,8 ± 31,7 ng/ml ( p = 0,00014). All patients, included into the study, significantly differed from practically healthy persons by PICP level 69,4 ± 23,9 ng/ml ( p