Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia.

Rim Frikha,Maha Ben Jemaa,Fakher Frikha,Ines Zouari Turki,Moez Elloumi,Leila Keskes,Hassen Kamoun,Tarek Rebai

Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia.

2020

Rim Frikha
Maha Ben Jemaa
Fakher Frikha
Ines Zouari Turki
Moez Elloumi
Leila Keskes
Hassen Kamoun
Tarek Rebai

BackgroundMethotrexate (MTX) is a key drug in acute lymphoblastic leukemia (ALL) treatment; it inhibits DNA replication by blocking the conversion of 5, 10 Methylenetetrahydrofolate to 5-methylene ...

Keywords:

Gastroenterology
Medicine
Toxicity
Genotype
Methotrexate
Methylenetetrahydrofolate reductase
Restriction fragment length polymorphism
Adverse effect
Genotyping
Mutation
Internal medicine

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