Activity, cognition and emotion : three dimensional pillars of the natural presentations of mood disorders enriched by the "sleep"fourth dimension (ACES).

What is the most accurate way to capture and organize the tremendous variability in symptoms that occur within and between mood states and over the course of time in bipolar disordersThis question regularly re-emerges underpinned by an equally fundamental question, which is the best treatment for a given patient. Indeed, the high clinical heterogeneity within a syndrome (e.g. depression), does not allow for relevant treatment recommendations.