Docking Studies on the Interaction of Imidazolines and Potassium Ion Channel-Kir6.2

Kir6.2,a key component of the ATP-sensitive potassium channel(KATP),can directly interact with imidazolines,a kind of potential antidiabetic drug.This paper explored the interaction of Kir6.2 with imidazoline molecules by applying AutoDock software.The docking results reveal the binding sites of the seven imidazolines on Kir6.2.For Efaroxan,Clonidine,Cibenzoline and Bl11282,polar residues,H175,K67and W68,constitute the binding pocket;while Rx871024,Alinidine and Ly389382,lies in a hydrophobic pocket which is composed of nonpolar residues,F168,M169 and I296.Efaroxan,Clonidine,Cibenzoline and Bl11282 interact with Kir6.2 mainly by forming hydrogen bonds,but for Rx871024,Alinidine and Ly389382,the hydrophobic interaction is the most important mode of action.These binding sites and the interaction modes can interpret the inhibition of these imidazoline drugs to some extent,and this research may provide theoretical support in the pharmacological study of imidazolines regulating the secretion of insulin.