Prediction value of preoperative findings on meningioma grading using artificial neural network

Abstract Objectives Meningioma is the most common brain tumor in adults. Grade 1 meningiomas have excellent prognoses, but grades 2 and 3 usually have worse outcomes, higher recurrence rates, and higher mortality rates. Preoperative determination of tumor grade may be helpful in deciding the type of surgery and the rate of resection. Blood markers have been used to predict the rate of malignancy and prognosis of tumors in different regions, including the brain. The current study investigated the use of blood markers on predicting meningioma grade. Patients and methods Patients with newly diagnosed meningiomas were retrospectively reviewed. Data on the patients’ demographics, tumor locations, blood markers, and tumor pathology grades was extracted. The relationship between preoperative findings and tumor grade was statistically analyzed, and using the same findings and an artificial neural network, the accuracy of tumor grade prediction was evaluated. Results This study included 95 patients, 69 cases (72.4 %) of grade 1, 23 cases of grade 2 (24.4 %) and 3 cases of grade 3 (3.2 %) meningiomas. Monocyte and neutrophil counts as well as lymphocyte-to-monocyte ratio (LMR) were significantly different between low grade and high grade meningiomas, with higher monocyte and neutrophil counts and higher LMR associated with high grade meningiomas (p  Conclusion A preoperative high monocyte count and high LMR are associated with high grade meningioma. An artificial neural network using preoperative data can acceptably be used to characterize meningioma tumor grades.