Etanercept attenuates the development of cerulein-induced acute pancreatitis in mice: a comparison with TNF-alpha genetic deletion.

ABSTRACTTNF-α plays a pivotal role in the pathogenesis of acute pancreatitis. Recent studies have shown that TNF-α inhibition significantly ameliorates the course of experimental acute pancreatitis, but in this context, the effects of Etanercept, a novel anti-TNF-α agent, have not been investigated