Anti-TGFβ (Transforming Growth Factor β) Therapy With Betaglycan-Derived P144 Peptide Gene Delivery Prevents the Formation of Aortic Aneurysm in a Mouse Model of Marfan Syndrome.

Cristina Arce,Isaac Rodríguez-Rovira,Karo De Rycke,Karina Durán,Victoria Campuzano,Isabel Fabregat,Francesc Jiménez-Altayó,Pedro Berraondo,Gustavo Egea

Anti-TGFβ (Transforming Growth Factor β) Therapy With Betaglycan-Derived P144 Peptide Gene Delivery Prevents the Formation of Aortic Aneurysm in a Mouse Model of Marfan Syndrome.

2021

Cristina Arce
Isaac Rodríguez-Rovira
Karo De Rycke
Karina Durán
Victoria Campuzano
Isabel Fabregat
Francesc Jiménez-Altayó
Pedro Berraondo
Gustavo Egea

Objective: We investigated the effect of a potent TGFβ (transforming growth factor β) inhibitor peptide (P144) from the betaglycan/TGFβ receptor III on aortic aneurysm development in a Marfan syndr...

Keywords:

Marfan syndrome
TGF beta signaling pathway
Peptide
Gene delivery
genetic therapy
Medicine
Cancer research
Aortic aneurysm
Transforming growth factor
Receptor

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