An assay method for cross-linked sodium hyaluronate gel, polyethylene glycol residues

The present invention discloses a method for detecting linked sodium hyaluronate gel, polyethylene glycol residues in a cross, formed according PEG barium and iodide ions 1: 1: Content of PEG optical density in a composite linear principle of unconventional solvent at 535nm established a simple, fast, good stability cross-linked gel method for detecting trace amounts of residual PEG. The detection method in 0-50.0? A good linear relationship μg / mL range, in particular a crosslinking agent may be used to detect the remaining amount of 2μg / mL or less and a high molecular weight. This detection method can be used not only sodium hyaluronate crosslinked PEG testing and quality control of trace amounts of residual products PEG gels, and other gels of other liquid samples containing PEG PEG PEG crosslinked residue amount detection is also important.