The (Extended) Ternary Complex Model ([E]TCM) for G Protein Activation

Many reviews have been written in which the mechanism of G protein activation is described. Several authors including Birnbaumer1–3 Chabre et al,4 Conklin and Bourne,5 Gilman,6,7 Rodbell8 and Stryer9 describe in detail how G proteins may be activated by GPCRs; extensive lists of references are presented loc. cit. I this subsection we summarize the most important findings.