Impact of waist-to-height ratio on newly onset of impaired fasting glucose and diabetes mellitus

Objective To analyze the impact of waist-to-height ratio(WHtR)on newly onset of impaired fasting glucose(IFG)and diabetes mellitus. Methods A total of 46 238 subjects were enrolled as the observation cohort. Their fasting plasma glucose(FPG)was below 5.6 mmol/L and there was no history of diabetes during the 2006-2007 health examination. Complete data of waist circumference, body height, and FPG were made in the 2012-2013 health examination. According to the baseline WHtR quartile, the observed cohort was divided into four groups, in which the incidences of newly onset of IFG and diabetes were compared. Multiple logistic regression analysis was used to analyze the influencing factor of newly onset of IFG and diabetes. Results (1) The incidences of newly onset IFG and diabetes were 46.88 per 1 000 person-years and 6.79 per 1 000 person-years respectively. Along with increasing WHtR in the 4 quartile groups, the incidences of newly onset IFG were progressively increased, being 10.37, 9.77, 13.10, and 13.64 per 1 000 person-years, respectively. The incidences of newly onset diabetes were 0.95, 1.11, 1.83, and 2.91 per 1 000 person-years in the 4 quartile groups, respectively. (2) Multiple logistic regression analysis showed that compared with the first quartile group, the second, third and forth quartile groups had increased risks of newly onset IFG, the RR value was 1.337, 1.560, and 1.839, respectively. The second, third, and forth quartile groups had also increased risks of newly onset diabetes, the RR value was 1.669, 2.335, and 4.170, respectively. Conclusion The incidences of newly onset IFG and diabetes are increased along with the increasing WHtR. (Chin J Endocrinol Metab, 2015, 31: 234-237) Key words: Waist-to-height ratio; Impaired fasting glucose; Diabetes mellitus