Thioredoxin-1 is required for the cardioprotecive effect of sildenafil against ischaemia/reperfusion injury and mitochondrial dysfunction in mice

AbstractSildenafil is a phosphodiesterase type 5 inhibitor which confers cardioprotection against myocardial ischemia/reperfusion (I/R) injury. The aim of this study was to determine if Trx1 partic...