Meta-analysis of risk factors for lung infection in patients with craniocerebral injury after tracheotomy

Objective To analyze the risk factors for lung infection in patients with craniocerebral injury after tracheotomy through Meta-analysis and provide a scientific reference for its prevention. Methods The inclusion and exclusion criteria were determined and the search strategies were designed. Two researchers independently searched both English and Chinese databases such as Cochrane Library, EMBASE, PubMed, CNKI, Wanfang and VIP (taking brain injury, craniocerebral injury, traumatic brain injury, tracheotomy, lung infection, pulmonary infection, risk factor, influencing factor and promotive factor as the key words) for literatures published since the databases were built to April 28th, 2019. RevMan 5.3 was used to analyze the data after the quality of literatures were assessed. Results Totally 9 articles were included, including 2 112 patients with craniocerebral injury. Meta-analysis showed that diabetes [OR=3.36, 95%CI(2.49, 4.54), P 7 d) [OR=2.32, 95%CI (1.42, 3.79); P< 0.01]were the influencing factors for lung infection in patients with craniocerebral injury after tracheotomy. Conclusions Existing evidence shows that combined with diabetes, use of hormones, high GCS score, hypoalbuminemia, occurrence of aspiration, use of non-irrigable tracheal cannula, smoking, tracheotomy time> 7 d were independent risk factors for lung infection in patients with craniocerebral injury. Key words: Craniocerebral injury; Meta-analysis; Tracheotomy; Risk factor; Lung infection